Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| B | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| B | 0005524 | molecular_function | ATP binding |
| B | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1743 |
| Chain | Residue |
| A | ALA447 |
| A | SER448 |
| A | MET602 |
| A | THR604 |
| A | SER606 |
| A | THR607 |
| A | HOH2019 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1744 |
| Chain | Residue |
| A | HOH2115 |
| A | HOH2118 |
| A | DTP1745 |
| A | HOH2114 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE DTP A 1745 |
| Chain | Residue |
| A | ASP226 |
| A | SER227 |
| A | ILE228 |
| A | ARG256 |
| A | ILE262 |
| A | ALA263 |
| A | GLY264 |
| A | MG1744 |
| A | HOH2026 |
| A | HOH2114 |
| A | HOH2115 |
| A | HOH2116 |
| A | HOH2117 |
| A | HOH2118 |
| B | LYS243 |
| B | TYR285 |
| B | VAL286 |
| B | ASP287 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE DTP B 1745 |
| Chain | Residue |
| A | LYS243 |
| A | TYR285 |
| A | VAL286 |
| A | ASP287 |
| B | ASP226 |
| B | SER227 |
| B | ILE228 |
| B | ARG256 |
| B | ILE262 |
| B | ALA263 |
| B | GLY264 |
| B | MG1746 |
| B | HOH2109 |
| B | HOH2110 |
| B | HOH2111 |
| B | HOH2112 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 1746 |
| Chain | Residue |
| B | DTP1745 |
| B | HOH2110 |
| B | HOH2111 |
| B | HOH2112 |
Functional Information from PROSITE/UniProt
| site_id | PS00089 |
| Number of Residues | 23 |
| Details | RIBORED_LARGE Ribonucleotide reductase large subunit signature. WkvLkekiakyGIRNsllIApmP |
| Chain | Residue | Details |
| A | TRP581-PRO603 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN427 | |
| A | GLU431 | |
| B | ASN427 | |
| B | GLU431 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Cysteine radical intermediate => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS429 | |
| B | CYS429 | |
| Chain | Residue | Details |
| A | SER202 | |
| B | THR604 | |
| A | SER217 | |
| A | ASN427 | |
| A | GLU431 | |
| A | THR604 | |
| B | SER202 | |
| B | SER217 | |
| B | ASN427 | |
| B | GLU431 | |
| Chain | Residue | Details |
| A | ASP226 | |
| A | LYS243 | |
| A | ARG256 | |
| A | ALA263 | |
| B | ASP226 | |
| B | LYS243 | |
| B | ARG256 | |
| B | ALA263 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Important for hydrogen atom transfer => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS218 | |
| A | CYS444 | |
| B | CYS218 | |
| B | CYS444 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | SITE: Important for electron transfer => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR737 | |
| A | TYR738 | |
| B | TYR737 | |
| B | TYR738 | |
| Chain | Residue | Details |
| A | LYS376 | |
| B | LYS376 | |
