2WG3

Crystal structure of the complex between human hedgehog-interacting protein HIP and desert hedgehog without calcium

Summary for 2WG3

Entry DOI	10.2210/pdb2wg3/pdb
Related	2WFQ 2WFR 2WFT 2WFX 2WG4
Descriptor	DESERT HEDGEHOG PROTEIN N-PRODUCT, HEDGEHOG-INTERACTING PROTEIN, ZINC ION, ... (7 entities in total)
Functional Keywords	lipoprotein, development, membrane, secreted, protease, palmitate, hydrolase, developmental protein, autocatalytic cleavage, signal transduction, egf-like domain, disease mutation, hedgehog signaling, glycoprotein, cell membrane, disulfide bond, signaling protein
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	141903.02
Authors	Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. (deposition date: 2009-04-15, release date: 2009-06-30, Last modification date: 2023-12-13)
Primary citation	Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16:698-, 2009 Cited by PubMed: 19561611 DOI: 10.1038/NSMB.1607 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation