2WFQ

Crystal structure of the N-terminal signalling domain of human Dhh without calcium

Summary for 2WFQ

Entry DOI	10.2210/pdb2wfq/pdb
Related	2WFR 2WFT 2WFX 2WG3 2WG4
Descriptor	DESERT HEDGEHOG PROTEIN N-PRODUCT, ZINC ION, SULFATE ION, ... (4 entities in total)
Functional Keywords	lipoprotein, development, cell membrane, autocatalytic cleavage, signaling protein, disease mutation, hedgehog signalling, protease, membrane, secreted, palmitate, hydrolase, signal transduction, developmental protein
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	19010.55
Authors	Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. (deposition date: 2009-04-14, release date: 2009-06-30, Last modification date: 2023-12-13)
Primary citation	Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16:698-, 2009 Cited by PubMed: 19561611 DOI: 10.1038/NSMB.1607 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation