2WBB
FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR
Summary for 2WBB
Entry DOI | 10.2210/pdb2wbb/pdb |
Related | 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBD |
Descriptor | FRUCTOSE-1,6-BISPHOSPHATASE 1, N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE (3 entities in total) |
Functional Keywords | phosphoric monoester, allosteric enzyme, carbohydrate metabolism, gluconeogenesis, hydrolase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 8 |
Total formula weight | 297885.34 |
Authors | Ruf, A.,Joseph, C.,Benz, J.,Fol, B.,Tetaz, T.,Kitas, E.,Mohr, P.,Kuhn, B.,Wessel, H.P.,Hebeisen, P.,Haap, W.,Huber, W.,Alvarez Sanchez, R.,Paehler, A.,Bernadeau, A.,Gubler, M.,Schott, B.,Tozzo, E. (deposition date: 2009-02-26, release date: 2009-12-22, Last modification date: 2023-12-13) |
Primary citation | Kitas, E.,Mohr, P.,Kuhn, B.,Wessel, H.P.,Hebeisen, P.,Haap, W.,Ruf, A.,Benz, J.,Joseph, C.,Huber, W.,Alvarez Sanchez, R.,Paehler, A.,Bernadeau, A.,Gubler, M.,Schott, B.,Tozzo, E. Sulfonylureido Thiazoles as Fructose-1,6-Bisphosphatase Inhibitors for the Treatment of Type-2 Diabetes. Bioorg.Med.Chem.Lett., 20:594-, 2010 Cited by PubMed: 19969452DOI: 10.1016/J.BMCL.2009.11.093 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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