2VT5
FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE -1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH A DUAL BINDING AMP SITE INHIBITOR
Summary for 2VT5
Entry DOI | 10.2210/pdb2vt5/pdb |
Related | 1FTA 2FHY 2FIE 2FIX 2JJK |
Descriptor | FRUCTOSE-1,6-BISPHOSPHATASE 1, 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE (3 entities in total) |
Functional Keywords | hydrolase (phosphoric monoester), disease mutation, allosteric enzyme, zinc, hydrolase, polymorphism, gluconeogenesis, carbohydrate metabolism |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 8 |
Total formula weight | 297078.13 |
Authors | Ruf, A.,Joseph, C.,Benz, J.,Fol, B.,Tetaz, T. (deposition date: 2008-05-09, release date: 2008-07-22, Last modification date: 2024-05-08) |
Primary citation | Hebeisen, P.,Kuhn, B.,Kohler, P.,Gubler, M.,Huber, W.,Kitas, E.,Schott, B.,Benz, J.,Joseph, C.,Ruf, A. Allosteric Fbpase Inhibitors Gain 10(5) Times in Potency When Simultaneously Binding Two Neighboring AMP Sites. Bioorg.Med.Chem.Lett., 18:4708-, 2008 Cited by PubMed: 18650089DOI: 10.1016/J.BMCL.2008.06.103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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