2VTD

Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor

Summary for 2VTD

Entry DOI	10.2210/pdb2vtd/pdb
Related	1E0D 1EEH 1UAG 2JFF 2JFG 2JFH 2UAG 2UUO 2UUP 2VTE 3UAG 4UAG
Descriptor	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, N-({6-[(4-CYANO-2-FLUOROBENZYL)OXY]NAPHTHALEN-2-YL}SULFONYL)-D-GLUTAMIC ACID, SULFATE ION, ... (4 entities in total)
Functional Keywords	murd-inhibitor complex, peptidoglycan synthesis, nucleotide-binding, sulfonamide inhibitor, murd ligase, atp-binding, cell division, ligase, cytoplasm, cell shape, cell cycle, cell wall biogenesis/degradation
Biological source	ESCHERICHIA COLI
Total number of polymer chains	1
Total formula weight	48561.93
Authors	Humljan, J.,Kotnik, M.,Contreras-Martel, C.,Blanot, D.,Urleb, U.,Dessen, A.,Solmajer, T.,Gobec, S. (deposition date: 2008-05-14, release date: 2008-11-25, Last modification date: 2023-12-13)
Primary citation	Humljan, J.,Kotnik, M.,Contreras-Martel, C.,Blanot, D.,Urleb, U.,Dessen, A.,Solmajer, T.,Gobec, S. Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme. J. Med. Chem., 51:7486-7494, 2008 Cited by PubMed: 19007109 DOI: 10.1021/jm800762u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation