2JFF

Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor

Summary for 2JFF

Entry DOI	10.2210/pdb2jff/pdb
Related	1E0D 1EEH 1UAG 2JFG 2JFH 2UAG 3UAG 4UAG
Descriptor	UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, N-[(6-BUTOXYNAPHTHALEN-2-YL)SULFONYL]-D-GLUTAMIC ACID, SULFATE ION, ... (4 entities in total)
Functional Keywords	murd-inhibitor complex, peptidoglycan synthesis, ligase, cell wall, cell shape, cell cycle, nucleotide-binding, sulfonamide inhibitor, murd ligase, atp-binding, cell division
Biological source	ESCHERICHIA COLI
Total number of polymer chains	1
Total formula weight	48580.98
Authors	Kotnik, M.,Humljan, J.,Contreras-Martel, C.,Oblak, M.,Kristan, K.,Herve, M.,Blanot, D.,Urleb, U.,Gobec, S.,Dessen, A.,Solmajer, T. (deposition date: 2007-02-01, release date: 2007-05-15, Last modification date: 2023-12-13)
Primary citation	Kotnik, M.,Humljan, J.,Contreras-Martel, C.,Oblak, M.,Kristan, K.,Herve, M.,Blanot, D.,Urleb, U.,Gobec, S.,Dessen, A.,Solmajer, T. Structural and Functional Characterization of Enantiomeric Glutamic Acid Derivatives as Potential Transition State Analogue Inhibitors of Murd Ligase. J.Mol.Biol., 370:107-, 2007 Cited by PubMed: 17507028 DOI: 10.1016/J.JMB.2007.04.048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation