2VGO
Crystal structure of Aurora B kinase in complex with Reversine inhibitor
Summary for 2VGO
Entry DOI | 10.2210/pdb2vgo/pdb |
Related | 2BFX 2BFY 2VGP |
Descriptor | SERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine, ... (4 entities in total) |
Functional Keywords | nucleotide-binding, serine/threonine-protein kinase, atp-binding, transferase, coiled coil, cell division, kinase, cancer, incenp, nucleus, mitosis, aurora b, metal-binding, aminothiazole, phosphorylation, magnesium, cell cycle, centromere, microtubule |
Biological source | XENOPUS LAEVIS (AFRICAN CLAWED FROG) More |
Cellular location | Nucleus: Q6DE08 Chromosome, centromere: O13024 |
Total number of polymer chains | 4 |
Total formula weight | 78010.22 |
Authors | D'Alise, A.M.,Amabile, G.,Iovino, M.,Di Giorgio, F.P.,Bartiromo, M.,Sessa, F.,Villa, F.,Musacchio, A.,Cortese, R. (deposition date: 2007-11-15, release date: 2008-10-28, Last modification date: 2024-01-31) |
Primary citation | D'Alise, A.M.,Amabile, G.,Iovino, M.,Di Giorgio, F.P.,Bartiromo, M.,Sessa, F.,Villa, F.,Musacchio, A.,Cortese, R. Reversine, a Novel Aurora Kinases Inhibitor, Inhibits Colony Formation of Human Acute Myeloid Leukemia Cells. Mol.Cancer Ther., 7:1140-, 2008 Cited by PubMed: 18483302DOI: 10.1158/1535-7163.MCT-07-2051 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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