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2VGP

Crystal structure of Aurora B kinase in complex with a aminothiazole inhibitor

Summary for 2VGP
Entry DOI10.2210/pdb2vgp/pdb
Related2BFX 2BFY 2VGO
DescriptorSERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, 4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzamide, ... (4 entities in total)
Functional Keywordsnucleotide-binding, serine/threonine-protein kinase, atp-binding, transferase, coiled coil, cell division, kinase, cancer, incenp, nucleus, mitosis, aurora b, metal-binding, aminothiazole, phosphorylation, magnesium, cell cycle, centromere, microtubule
Biological sourceXENOPUS LAEVIS (AFRICAN CLAWED FROG)
More
Cellular locationNucleus: Q6DE08
Chromosome, centromere: O13024
Total number of polymer chains4
Total formula weight77653.39
Authors
Andersen, C.B.,Wan, Y.,Chang, J.W.,Lee, C.,Liu, Y.,Sessa, F.,Villa, F.,Nallan, L.,Musacchio, A.,Gray, N.S. (deposition date: 2007-11-15, release date: 2008-02-26, Last modification date: 2023-12-13)
Primary citationAndersen, C.B.,Wan, Y.,Chang, J.W.,Riggs, B.,Lee, C.,Liu, Y.,Sessa, F.,Villa, F.,Kwiatkowski, N.,Suzuki, M.,Nallan, L.,Heald, R.,Musacchio, A.,Gray, N.S.
Discovery of Selective Aminothiazole Aurora Kinase Inhibitors
Acs Chem.Biol., 3:180-, 2008
Cited by
PubMed: 18307303
DOI: 10.1021/CB700200W
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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