2VFA

Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases

Summary for 2VFA

Entry DOI	10.2210/pdb2vfa/pdb
Related	1BZY 1CJB 1D6N 1HMP 1Z7G
Descriptor	HYPOXANTHINE-GUANINE-XANTHINE PHOSPHORIBOSYLTRANSFERASE, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, GUANOSINE-5'-MONOPHOSPHATE, SULFATE ION, ... (4 entities in total)
Functional Keywords	hypoxanthine-guanine phosphoribosyl transferase (hgprt), purine salvage, disease mutation, glycosyltransferase, transferase, metal-binding, gout, chimera, magnesium
Biological source	PLASMODIUM FALCIPARUM More
Cellular location	Cytoplasm: P20035
Total number of polymer chains	2
Total formula weight	52584.45
Authors	Gayathri, P.,Selvi, T.S.,Subbayya, I.N.S.,Ashok, C.S.,Balaram, H.,Murthy, M.R.N. (deposition date: 2007-11-02, release date: 2008-06-17, Last modification date: 2023-12-13)
Primary citation	Gayathri, P.,Sujay Subbayya, I.N.,Ashok, C.S.,Selvi, T.S.,Balaram, H.,Murthy, M.R.N. Crystal Structure of a Chimera of Human and Plasmodium Falciparum Hypoxanthine Guanine Phosphoribosyltransferases Provides Insights Into Oligomerization. Proteins, 73:1010-, 2008 Cited by PubMed: 18536021 DOI: 10.1002/PROT.22129 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation