2V1Y
Structure of a phosphoinositide 3-kinase alpha adaptor-binding domain (ABD) in a complex with the iSH2 domain from p85 alpha
Summary for 2V1Y
Entry DOI | 10.2210/pdb2v1y/pdb |
Related | 1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI |
Descriptor | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA (3 entities in total) |
Functional Keywords | kinase, cancer, sh2 domain, sh3 domain, transferase, oncogenic mutations, host-virus interaction, phosphorylation, disease mutation, phosphoinositide, phospholipid, phospholipid signalling, phosphoinositide 3-kinase, signal transduction |
Biological source | BOS TAURUS (BOVINE) More |
Total number of polymer chains | 2 |
Total formula weight | 34044.88 |
Authors | Miled, N.,Yan, Y.,Hon, W.C.,Perisic, O.,Zvelebil, M.,Inbar, Y.,Schneidman-Duhovny, D.,Wolfson, H.J.,Backer, J.M.,Williams, R.L. (deposition date: 2007-05-30, release date: 2007-07-24, Last modification date: 2011-07-13) |
Primary citation | Miled, N.,Yan, Y.,Hon, W.C.,Perisic, O.,Zvelebil, M.,Inbar, Y.,Schneidman-Duhovny, D.,Wolfson, H.J.,Backer, J.M.,Williams, R.L. Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit. Science, 317:239-, 2007 Cited by PubMed: 17626883DOI: 10.1126/SCIENCE.1135394 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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