2UUH
Crystal structure of Human Leukotriene C4 Synthase in complex with substrate glutathione
Summary for 2UUH
Entry DOI | 10.2210/pdb2uuh/pdb |
Related | 2UUI |
Descriptor | LEUKOTRIENE C4 SYNTHASE, NICKEL (II) ION, DODECYL-ALPHA-D-MALTOSIDE, ... (8 entities in total) |
Functional Keywords | membrane protein, leukotriene signalling, lyase, mapeg, human, ltc4s, enzyme, trimer, membrane, leukotriene biosynthesis, eicosanoid, glutathione, transmembrane |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus outer membrane; Multi-pass membrane protein: Q16873 |
Total number of polymer chains | 1 |
Total formula weight | 19979.46 |
Authors | Martinez Molina, D.,Wetterholm, A.,Kohl, A.,McCarthy, A.A.,Niegowski, D.,Ohlson, E.,Hammarberg, T.,Eshaghi, S.,Haeggstrom, J.Z.,Nordlund, P. (deposition date: 2007-03-02, release date: 2007-07-17, Last modification date: 2024-05-08) |
Primary citation | Martinez Molina, D.,Wetterholm, A.,Kohl, A.,Mccarthy, A.A.,Niegowski, D.,Ohlson, E.,Hammarberg, T.,Eshaghi, S.,Haeggstrom, J.Z.,Nordlund, P. Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase. Nature, 448:613-, 2007 Cited by PubMed: 17632546DOI: 10.1038/NATURE06009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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