2Q7M

Crystal structure of human FLAP with MK-591

Summary for 2Q7M

• Entry DOI: 10.2210/pdb2q7m/pdb
• Related: 2Q7R
• Descriptor: Arachidonate 5-lipoxygenase-activating protein, 3-[3-(TERT-BUTYLTHIO)-1-(4-CHLOROBENZYL)-5-(QUINOLIN-2-YLMETHOXY)-1H-INDOL-2-YL]-2,2-DIMETHYLPROPANOIC ACID (2 entities in total)
• Functional Keywords: mapeg, membrane protein, flap, lipid transport
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus membrane; Multi-pass membrane protein: P20292
• Total number of polymer chains: 6
• Total formula weight: 112194.49

Authors

Ferguson, A.D. (deposition date: 2007-06-07, release date: 2007-08-21, Last modification date: 2024-02-21)

• Primary citation: Ferguson, A.D.,McKeever, B.M.,Xu, S.,Wisniewski, D.,Miller, D.K.,Yamin, T.T.,Spencer, R.H.,Chu, L.,Ujjainwalla, F.,Cunningham, B.R.,Evans, J.F.,Becker, J.W.; Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.; Science, 317:510-512, 2007; PubMed: 17600184; DOI: 10.1126/science.1144346

Experimental method

X-RAY DIFFRACTION (4.25 Å)