2Q7R

Crystal structure of human FLAP with an iodinated analog of MK-591

Summary for 2Q7R

• Entry DOI: 10.2210/pdb2q7r/pdb
• Related: 2q7m
• Descriptor: Arachidonate 5-lipoxygenase-activating protein, 3-[3-(3,3-DIMETHYLBUTANOYL)-1-(4-IODOBENZYL)-5-(QUINOLIN-2-YLMETHOXY)-1H-INDOL-2-YL]-2,2-DIMETHYLPROPANOIC ACID (2 entities in total)
• Functional Keywords: flap, mapeg, membrane protein, lipid transport
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus membrane; Multi-pass membrane protein: P20292
• Total number of polymer chains: 6
• Total formula weight: 113647.14

Authors

Ferguson, A.D. (deposition date: 2007-06-07, release date: 2007-08-21, Last modification date: 2021-10-20)

• Primary citation: Ferguson, A.D.,McKeever, B.M.,Xu, S.,Wisniewski, D.,Miller, D.K.,Yamin, T.T.,Spencer, R.H.,Chu, L.,Ujjainwalla, F.,Cunningham, B.R.,Evans, J.F.,Becker, J.W.; Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.; Science, 317:510-512, 2007; PubMed: 17600184; DOI: 10.1126/science.1144346

Experimental method

X-RAY DIFFRACTION (4 Å)