2Q6B
Design and synthesis of novel, conformationally restricted HMG-COA reductase inhibitors
Summary for 2Q6B
Entry DOI | 10.2210/pdb2q6b/pdb |
Related | 2Q1L 2Q6C |
Descriptor | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION, (3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID, ... (4 entities in total) |
Functional Keywords | oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph, statin |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035 |
Total number of polymer chains | 4 |
Total formula weight | 192392.89 |
Authors | Pavlovsky, A.,Pfefferkorn, J.A.,Harris, M.S.,Finzel, B.C. (deposition date: 2007-06-04, release date: 2007-07-17, Last modification date: 2024-02-21) |
Primary citation | Pfefferkorn, J.A.,Choi, C.,Song, Y.,Trivedi, B.K.,Larsen, S.D.,Askew, V.,Dillon, L.,Hanselman, J.C.,Lin, Z.,Lu, G.,Robertson, A.,Sekerke, C.,Auerbach, B.,Pavlovsky, A.,Harris, M.S.,Bainbridge, G.,Caspers, N. Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors. Bioorg.Med.Chem.Lett., 17:4531-4537, 2007 Cited by PubMed: 17574411DOI: 10.1016/j.bmcl.2007.05.097 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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