2Q1L

Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors

Summary for 2Q1L

Entry DOI	10.2210/pdb2q1l/pdb
Descriptor	3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID (3 entities in total)
Functional Keywords	oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph, statin
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035
Total number of polymer chains	4
Total formula weight	192224.72
Authors	Pavlovsky, A.,Pfefferkorn, J.A.,Harris, M.S.,Finzel, B.C. (deposition date: 2007-05-24, release date: 2007-07-17, Last modification date: 2024-02-21)
Primary citation	Pfefferkorn, J.A.,Song, Y.,Sun, K.L.,Miller, S.R.,Trivedi, B.K.,Choi, C.,Sorenson, R.J.,Bratton, L.D.,Unangst, P.C.,Larsen, S.D.,Poel, T.J.,Cheng, X.M.,Lee, C.,Erasga, N.,Auerbach, B.,Askew, V.,Dillon, L.,Hanselman, J.C.,Lin, Z.,Lu, G.,Robertson, A.,Olsen, K.,Mertz, T.,Sekerke, C.,Pavlovsky, A.,Harris, M.S.,Bainbridge, G.,Caspers, N.,Chen, H.,Eberstadt, M. Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Bioorg.Med.Chem.Lett., 17:4538-4544, 2007 Cited by PubMed: 17574412 DOI: 10.1016/j.bmcl.2007.05.096 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation