2PJL
Crystal Structure of Human Estrogen-Related Receptor alpha in Complex with a Synthetic Inverse Agonist reveals its Novel Molecular Mechanism
Summary for 2PJL
Entry DOI | 10.2210/pdb2pjl/pdb |
Related | 1XB7 |
Descriptor | Steroid hormone receptor ERR1, 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE (3 entities in total) |
Functional Keywords | nuclear hormone receptor, ligand binding domain, ligand binding pocket, three-layered alpha-helical sandwich, inverse agonist, helix 12 (h12), coactivator groove, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P11474 |
Total number of polymer chains | 2 |
Total formula weight | 54699.16 |
Authors | Kallen, J. (deposition date: 2007-04-16, release date: 2007-06-12, Last modification date: 2023-08-30) |
Primary citation | Kallen, J.,Lattmann, R.,Beerli, R.,Blechschmidt, A.,Blommers, M.J.,Geiser, M.,Ottl, J.,Schlaeppi, J.M.,Strauss, A.,Fournier, B. Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism. J.Biol.Chem., 282:23231-23239, 2007 Cited by PubMed: 17556356DOI: 10.1074/jbc.M703337200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report