2P86
The high resolution crystal structure of rhodesain, the major cathepsin L protease from T. brucei rhodesiense, bound to inhibitor K11002
Summary for 2P86
Entry DOI | 10.2210/pdb2p86/pdb |
Related | 2P7U |
Descriptor | Cysteine protease, 3-[[N-[MORPHOLIN-N-YL]-CARBONYL]-PHENYLALANINYL-AMINO]-5- PHENYL-PENTANE-1-SULFONYLBENZENE, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | cysteine protease, trypanosoma brucei, neglected disease, hydrolase |
Biological source | Trypanosoma brucei rhodesiense |
Total number of polymer chains | 1 |
Total formula weight | 24149.64 |
Authors | Brinen, L.S.,Marion, R. (deposition date: 2007-03-21, release date: 2008-04-01, Last modification date: 2023-08-30) |
Primary citation | Marion, R.,Hansell, E.,Caffrey, C.,Roush, W.R.,Brinen, L.S. THE high resolution structure of rhodesain, the major cathepsin L protease from trypanosoma brucei rhodesiense, illustrates the basis for differences in inhibition profiles from other papain family cysteine proteases To be Published, |
Experimental method | X-RAY DIFFRACTION (1.16 Å) |
Structure validation
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