2P7U
The crystal structure of rhodesain, the major cysteine protease of T. brucei rhodesiense, bound to inhibitor K777
Summary for 2P7U
Entry DOI | 10.2210/pdb2p7u/pdb |
Descriptor | Cysteine protease, NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE (3 entities in total) |
Functional Keywords | cysteine protease, trypanosoma brucei, neglected disease, hydrolase |
Biological source | Trypanosoma brucei rhodesiense |
Total number of polymer chains | 1 |
Total formula weight | 23479.94 |
Authors | Brinen, L.S.,Marion, R. (deposition date: 2007-03-20, release date: 2008-03-25, Last modification date: 2023-08-30) |
Primary citation | Kerr, I.D.,Lee, J.H.,Farady, C.J.,Marion, R.,Rickert, M.,Sajid, M.,Pandey, K.C.,Caffrey, C.R.,Legac, J.,Hansell, E.,McKerrow, J.H.,Craik, C.S.,Rosenthal, P.J.,Brinen, L.S. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J.Biol.Chem., 284:25697-25703, 2009 Cited by PubMed: 19620707DOI: 10.1074/jbc.M109.014340 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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