2OHP
X-ray crystal structure of beta secretase complexed with compound 3
Summary for 2OHP
Entry DOI | 10.2210/pdb2ohp/pdb |
Related | 2OF0 2OHK 2OHL 2OHM 2OHN 2OHQ 2OHR 2OHS 2OHT 2OHU |
Descriptor | Beta-secretase 1, IODIDE ION, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | alternative splicing, alzheimer's disease, aspartic protease, aspartyl protease, base, beta-secretase, glycoprotein, hydrolase, memapsin 2, transmembrane, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 45410.64 |
Authors | Patel, S. (deposition date: 2007-01-10, release date: 2007-05-01, Last modification date: 2023-08-30) |
Primary citation | Congreve, M.,Aharony, D.,Albert, J.,Callaghan, O.,Campbell, J.,Carr, R.A.,Chessari, G.,Cowan, S.,Edwards, P.D.,Frederickson, M.,McMenamin, R.,Murray, C.W.,Patel, S.,Wallis, N. Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase. J.Med.Chem., 50:1124-1132, 2007 Cited by PubMed: 17315857DOI: 10.1021/jm061197u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
Download full validation report