2OHM
X-ray crystal structure of beta secretase complexed with N~3~-benzylpyridine-2,3-diamine
Summary for 2OHM
Entry DOI | 10.2210/pdb2ohm/pdb |
Related | 2OF0 2OHK 2OHL 2OHN 2OHP 2OHQ 2OHR 2OHS 2OHT 2OHU |
Descriptor | Beta-secretase 1, IODIDE ION, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | alternative splicing, alzheimer's disease, aspartic protease, aspartyl protease, base, beta-secretase, glycoprotein, hydrolase, memapsin 2, transmembrane, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 45372.59 |
Authors | Patel, S. (deposition date: 2007-01-10, release date: 2007-03-13, Last modification date: 2023-08-30) |
Primary citation | Murray, C.W.,Callaghan, O.,Chessari, G.,Cleasby, A.,Congreve, M.,Frederickson, M.,Hartshorn, M.J.,McMenamin, R.,Patel, S.,Wallis, N. Application of fragment screening by X-ray crystallography to beta-Secretase. J.Med.Chem., 50:1116-1123, 2007 Cited by PubMed: 17315856DOI: 10.1021/jm0611962 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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