2HZN

Abl kinase domain in complex with NVP-AFG210

Summary for 2HZN

Entry DOI	10.2210/pdb2hzn/pdb
Related	2HYY 2HZ0 2HZ4 2HZI
Descriptor	Proto-oncogene tyrosine-protein kinase ABL1, 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA (2 entities in total)
Functional Keywords	tyrosine kinase, transferase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	1
Total formula weight	34116.85
Authors	Cowan-Jacob, S.W.,Fendrich, G.,Liebetanz, J.,Fabbro, D.,Manley, P. (deposition date: 2006-08-09, release date: 2007-01-16, Last modification date: 2023-08-30)
Primary citation	Cowan-Jacob, S.W.,Fendrich, G.,Floersheimer, A.,Furet, P.,Liebetanz, J.,Rummel, G.,Rheinberger, P.,Centeleghe, M.,Fabbro, D.,Manley, P.W. Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia. ACTA CRYSTALLOGR.,SECT.D, 63:80-93, 2007 Cited by PubMed: 17164530 DOI: 10.1107/S0907444906047287 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation