2HYY
Human Abl kinase domain in complex with imatinib (STI571, Glivec)
Summary for 2HYY
Entry DOI | 10.2210/pdb2hyy/pdb |
Related | 1FPU 1IEP |
Descriptor | Proto-oncogene tyrosine-protein kinase ABL1, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE (3 entities in total) |
Functional Keywords | tyrosine kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519 |
Total number of polymer chains | 4 |
Total formula weight | 128687.54 |
Authors | Cowan-Jacob, S.W.,Fendrich, G.,Liebetanz, J.,Fabbro, D.,Manley, P. (deposition date: 2006-08-08, release date: 2007-01-16, Last modification date: 2023-08-30) |
Primary citation | Cowan-Jacob, S.W.,Fendrich, G.,Floersheimer, A.,Furet, P.,Liebetanz, J.,Rummel, G.,Rheinberger, P.,Centeleghe, M.,Fabbro, D.,Manley, P.W. Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia. ACTA CRYSTALLOGR.,SECT.D, 63:80-93, 2007 Cited by PubMed: 17164530DOI: 10.1107/S0907444906047287 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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