2D1X
The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex
Summary for 2D1X
Entry DOI | 10.2210/pdb2d1x/pdb |
Descriptor | cortactin isoform a, proline rich region from development and differentiation enhancing factor 1, SULFATE ION, ... (4 entities in total) |
Functional Keywords | sh3, proline-rich, complex, cell invasion |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm, cytoskeleton: Q14247 |
Total number of polymer chains | 6 |
Total formula weight | 32944.26 |
Authors | Hashimoto, S.,Hirose, M.,Hashimoto, A.,Morishige, M.,Yamada, A.,Hosaka, H.,Akagi, K.,Ogawa, E.,Oneyama, C.,Agatsuma, T.,Okada, M.,Kobayashi, H.,Wada, H.,Nakano, H.,Ikegami, T.,Nakagawa, A.,Sabe, H. (deposition date: 2005-09-01, release date: 2006-04-25, Last modification date: 2024-03-13) |
Primary citation | Hashimoto, S.,Hirose, M.,Hashimoto, A.,Morishige, M.,Yamada, A.,Hosaka, H.,Akagi, K.,Ogawa, E.,Oneyama, C.,Agatsuma, T.,Okada, M.,Kobayashi, H.,Wada, H.,Nakano, H.,Ikegami, T.,Nakagawa, A.,Sabe, H. Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. Proc.Natl.Acad.Sci.Usa, 103:7036-7041, 2006 Cited by PubMed: 16636290DOI: 10.1073/pnas.0509166103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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