1XU7
Crystal Structure of the Interface Open Conformation of Tetrameric 11b-HSD1
Summary for 1XU7
Entry DOI | 10.2210/pdb1xu7/pdb |
Related | 1XU9 |
Descriptor | Corticosteroid 11-beta-dehydrogenase, isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ... (4 entities in total) |
Functional Keywords | 11b-hsd1, sdr, dehydrogenase, hydroxysteroid, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845 |
Total number of polymer chains | 4 |
Total formula weight | 134018.45 |
Authors | Hosfield, D.J.,Wu, Y.,Skene, R.J.,Hilger, M.,Jennings, A.,Snell, G.P.,Aertgeerts, K. (deposition date: 2004-10-25, release date: 2004-11-02, Last modification date: 2024-02-14) |
Primary citation | Hosfield, D.J.,Wu, Y.,Skene, R.J.,Hilger, M.,Jennings, A.,Snell, G.P.,Aertgeerts, K. Conformational Flexibility in Crystal Structures of Human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation. J.Biol.Chem., 280:4639-4648, 2005 Cited by PubMed: 15513927DOI: 10.1074/jbc.M411104200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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