1XKK
EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
1XKK の概要
エントリーDOI | 10.2210/pdb1xkk/pdb |
分子名称 | Epidermal growth factor receptor, PHOSPHATE ION, N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE, ... (4 entities in total) |
機能のキーワード | egfr, epidermal growth factor receptor, kinase, transferase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 41095.41 |
構造登録者 | Wood, E.R.,Truesdale, A.T.,McDonald, O.B.,Yuan, D.,Hassell, A.,Dickerson, S.H.,Ellis, B.,Pennisi, C.,Horne, E.,Lackey, K.,Alligood, K.J.,Rusnak, D.W.,Gilmer, T.M.,Shewchuk, L.M. (登録日: 2004-09-29, 公開日: 2004-12-07, 最終更新日: 2023-08-23) |
主引用文献 | Wood, E.R.,Truesdale, A.T.,McDonald, O.B.,Yuan, D.,Hassell, A.,Dickerson, S.H.,Ellis, B.,Pennisi, C.,Horne, E.,Lackey, K.,Alligood, K.J.,Rusnak, D.W.,Gilmer, T.M.,Shewchuk, L. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res., 64:6652-6659, 2004 Cited by PubMed: 15374980DOI: 10.1158/0008-5472.CAN-04-1168 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.4 Å) |
構造検証レポート
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