1X2R
Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
Summary for 1X2R
Entry DOI | 10.2210/pdb1x2r/pdb |
Related | 1X2J |
Descriptor | Kelch-like ECH-associated protein 1, Nuclear factor erythroid 2 related factor 2, SULFATE ION, ... (4 entities in total) |
Functional Keywords | beta propeller, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transcription |
Biological source | Mus musculus (house mouse) More |
Cellular location | Cytoplasm: Q9Z2X8 Cytoplasm, cytosol: Q60795 |
Total number of polymer chains | 2 |
Total formula weight | 36628.56 |
Authors | Padmanabhan, B.,Tong, K.I.,Nakamura, Y.,Ohta, T.,Scharlock, M.,Kobayashi, A.,Ohtsuji, M.,Kang, M.-I.,Yamamoto, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2005-04-26, release date: 2006-03-07, Last modification date: 2023-10-25) |
Primary citation | Padmanabhan, B.,Tong, K.I.,Ohta, T.,Nakamura, Y.,Scharlock, M.,Ohtsuji, M.,Kang, M.-I.,Kobayashi, A.,Yokoyama, S.,Yamamoto, M. Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer Mol.Cell, 21:689-700, 2006 Cited by PubMed: 16507366DOI: 10.1016/j.molcel.2006.01.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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