1X2J
Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
Summary for 1X2J
Entry DOI | 10.2210/pdb1x2j/pdb |
Related | 1X2R |
Descriptor | Kelch-like ECH-associated protein 1, SULFATE ION (3 entities in total) |
Functional Keywords | beta propeller, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transcription |
Biological source | Mus musculus (house mouse) |
Cellular location | Cytoplasm: Q9Z2X8 |
Total number of polymer chains | 1 |
Total formula weight | 35480.41 |
Authors | Padmanabhan, B.,Tong, K.I.,Nakamura, Y.,Ohta, T.,Scharlock, M.,Kobayashi, A.,Ohtsuji, M.,Kang, M.-I.,Yamamoto, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2005-04-25, release date: 2006-03-07, Last modification date: 2024-03-13) |
Primary citation | Padmanabhan, B.,Tong, K.I.,Ohta, T.,Nakamura, Y.,Scharlock, M.,Ohtsuji, M.,Kang, M.-I.,Kobayashi, A.,Yokoyama, S.,Yamamoto, M. Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer Mol.Cell, 21:689-700, 2006 Cited by PubMed: 16507366DOI: 10.1016/j.molcel.2006.01.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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