1W6J
Structure of human OSC in complex with Ro 48-8071
Summary for 1W6J
Entry DOI | 10.2210/pdb1w6j/pdb |
Descriptor | LANOSTEROL SYNTHASE, [4-({6-[ALLYL(METHYL)AMINO]HEXYL}OXY)-2-FLUOROPHENYL](4-BROMOPHENYL)METHANONE, octyl beta-D-glucopyranoside, ... (5 entities in total) |
Functional Keywords | cyclase, cholesterol, lanosterol, monotopic membrane protein, b-octyl-glucoside, isomerase, steroid biosynthesis |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein : P48449 |
Total number of polymer chains | 1 |
Total formula weight | 84930.51 |
Authors | Thoma, R.,Schulz-Gasch, T.,D'Arcy, B.,Benz, J.,Aebi, J.,Dehmlow, H.,Hennig, M.,Ruf, A. (deposition date: 2004-08-18, release date: 2004-10-29, Last modification date: 2023-12-13) |
Primary citation | Thoma, R.,Schulz-Gasch, T.,D'Arcy, B.,Benz, J.,Aebi, J.,Dehmlow, H.,Hennig, M.,Stihle, M.,Ruf, A. Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase Nature, 432:118-, 2004 Cited by PubMed: 15525992DOI: 10.1038/NATURE02993 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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