1UWJ

The complex of mutant V599E B-RAF and BAY439006.

Summary for 1UWJ

Entry DOI	10.2210/pdb1uwj/pdb
Related	1UWH
Descriptor	B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE (3 entities in total)
Functional Keywords	transferase, threonine-protein kinase, signal transduction
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : P15056
Total number of polymer chains	2
Total formula weight	63950.63
Authors	Barford, D.,Roe, S.M.,Wan, P.T.C.,Cancer Genome Project (deposition date: 2004-02-05, release date: 2004-03-19, Last modification date: 2018-01-17)
Primary citation	Wan, P.T.C.,Garnett, M.J.,Roe, S.M.,Lee, S.,Niculescu-Duvaz, D.,Good, V.M.,Jones, C.M.,Marshall, C.J.,Springer, C.J.,Barford, D.,Marais, R. Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf Cell(Cambridge,Mass.), 116:855-, 2004 Cited by PubMed: 15035987 DOI: 10.1016/S0092-8674(04)00215-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation