1U70
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase
Summary for 1U70
| Entry DOI | 10.2210/pdb1u70/pdb |
| Descriptor | Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
| Functional Keywords | variant dhfr mouse, human, oxidoreductase |
| Biological source | Mus musculus (house mouse) |
| Cellular location | Mitochondrion : P00375 |
| Total number of polymer chains | 1 |
| Total formula weight | 22747.74 |
| Authors | Cody, V. (deposition date: 2004-08-02, release date: 2005-02-01, Last modification date: 2024-02-14) |
| Primary citation | Cody, V.,Luft, J.R.,Pangborn, W. Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr.,Sect.D, 61:147-155, 2005 Cited by PubMed: 15681865DOI: 10.1107/S0907444904030422 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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