1U70
Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydrofolate reductase | polymer | 186 | 21547.9 | 1 | UniProt (P00375) Pfam (PF00186) In PDB | Mus musculus (house mouse) | |
2 | A | METHOTREXATE | non-polymer | 454.4 | 1 | Chemie (MTX) | |||
3 | A | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
4 | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A: 1 - 186 (UniProt: P00375)
PDB | External Database | Details |
---|---|---|
Arg 22 | Leu 22 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 21547.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1199.9 | |
All* | Total formula weight | 22747.7 |