1TJH
Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 11mer epitope
Summary for 1TJH
Entry DOI | 10.2210/pdb1tjh/pdb |
Related | 1TJG 1TJI 2F5B |
Descriptor | anti-HIV-1 antibody 2F5 Light Chain, anti-HIV-1 antibody 2F5 Heavy Chain, Envelope glycoprotein GP41, ... (6 entities in total) |
Functional Keywords | 2f5, antibody, gp41, hiv-1, neutralizing, membrane-proximal, viral protein-immune system complex, viral protein/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: P04580 |
Total number of polymer chains | 3 |
Total formula weight | 50533.01 |
Authors | Ofek, G.,Tang, M.,Sambor, A.,Katinger, H.,Mascola, J.R.,Wyatt, R.,Kwong, P.D. (deposition date: 2004-06-04, release date: 2004-10-05, Last modification date: 2023-08-23) |
Primary citation | Ofek, G.,Tang, M.,Sambor, A.,Katinger, H.,Mascola, J.R.,Wyatt, R.,Kwong, P.D. Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope J.Virol., 78:10724-10737, 2004 Cited by PubMed: 15367639DOI: 10.1128/JVI.78.19.10724-10737.2004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report