1TJG

Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 7mer epitope

Summary for 1TJG

• Entry DOI: 10.2210/pdb1tjg/pdb
• Related: 1TJH 1TJI 2F5B
• Descriptor: FAB 2F5 Light Chain, FAB 2F5 Heavy Chain, Envelope glycoprotein GP41, ... (6 entities in total)
• Functional Keywords: 2f5; antibody; gp41; hiv-1; neutralizing; membrane-proximal, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 50105.44

Authors

Ofek, G.,Tang, M.,Sambor, A.,Katinger, H.,Mascola, J.R.,Wyatt, R.,Kwong, P.D. (deposition date: 2004-06-04, release date: 2004-10-05, Last modification date: 2023-08-23)

• Primary citation: Ofek, G.,Tang, M.,Sambor, A.,Katinger, H.,Mascola, J.R.,Wyatt, R.,Kwong, P.D.; Structure and mechanistic analysis of the Anti-Human Immunodeficiency Virus Type 1 antibody 2F5 in complex with its gp41 epitope; J.Virol., 78:10724-10737, 2004; PubMed: 15367639; DOI: 10.1128/JVI.78.19.10724-10737.2004

Experimental method

X-RAY DIFFRACTION (2 Å)