1T46
STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE
Summary for 1T46
Entry DOI | 10.2210/pdb1t46/pdb |
Related | 1PKG 1T45 |
Descriptor | Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, PHOSPHATE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, sti-571, gleevec, transferase activator |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 36072.48 |
Authors | Mol, C.D.,Dougan, D.R.,Schneider, T.R.,Skene, R.J.,Kraus, M.L.,Scheibe, D.N.,Snell, G.P.,Zou, H.,Sang, B.C.,Wilson, K.P. (deposition date: 2004-04-28, release date: 2004-06-15, Last modification date: 2024-02-14) |
Primary citation | Mol, C.D.,Dougan, D.R.,Schneider, T.R.,Skene, R.J.,Kraus, M.L.,Scheibe, D.N.,Snell, G.P.,Zou, H.,Sang, B.C.,Wilson, K.P. Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase. J.Biol.Chem., 279:31655-31663, 2004 Cited by PubMed: 15123710DOI: 10.1074/jbc.M403319200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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