1SI2

Crystal structure of the PAZ domain of human eIF2c1 in complex with a 9-mer siRNA-like duplex of deoxynucleotide overhang

Summary for 1SI2

• Entry DOI: 10.2210/pdb1si2/pdb
• Related: 1SI3
• Descriptor: 5'-R(*CP*GP*UP*GP*AP*CP*U)-D(P*CP*T)-3', Eukaryotic translation initiation factor 2C 1 (3 entities in total)
• Functional Keywords: protein-rna complex, rna interference, double helix, overhang, gene regulation-rna-dna complex, gene regulation/rna/dna
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, P-body: Q9UL18
• Total number of polymer chains: 2
• Total formula weight: 19980.71

Authors

Ye, K.,Ma, J.B.,Patel, D. (deposition date: 2004-02-26, release date: 2004-05-25, Last modification date: 2024-02-14)

• Primary citation: Ma, J.B.,Ye, K.,Patel, D.J.; Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain.; Nature, 429:318-322, 2004; PubMed: 15152257; DOI: 10.1038/nature02519

Experimental method

X-RAY DIFFRACTION (2.6 Å)