1QXE
Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds
Summary for 1QXE
Entry DOI | 10.2210/pdb1qxe/pdb |
Related | 1QXD |
Descriptor | Hemoglobin alpha chain, Hemoglobin beta chain, SULFATE ION, ... (7 entities in total) |
Functional Keywords | allosteric; antisickling; relaxed state; hemoglobin; sickle cell; 5-hydroxymethyl-2-furfural, oxygen storage-transport complex, oxygen storage/transport |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 65599.71 |
Authors | Safo, M.K.,Abdulmalik, O.,Danso-Danquah, R.,Nokuri, S.,Joshi, G.S.,Musayev, F.N.,Asakura, T.,Abraham, D.J. (deposition date: 2003-09-05, release date: 2003-09-16, Last modification date: 2023-08-23) |
Primary citation | Safo, M.K.,Abdulmalik, O.,Danso-Danquah, R.,Burnett, J.C.,Nokuri, S.,Joshi, G.S.,Musayev, F.N.,Asakura, T.,Abraham, D.J. Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds J.Med.Chem., 47:4665-4676, 2004 Cited by PubMed: 15341482DOI: 10.1021/jm0498001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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