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1QXD

Structural Basis for the Potent Antisickling Effect of a Novel Class of 5-Membered Heterocyclic Aldehydic Compounds

Summary for 1QXD
Entry DOI10.2210/pdb1qxd/pdb
Related1QXE
DescriptorHemoglobin alpha chain, Hemoglobin beta chain, SULFATE ION, ... (6 entities in total)
Functional Keywordsallosteric; antisickling; relaxed state; hemoglobin; sickle cell; furfural, oxygen storage-transport complex, oxygen storage/transport
Biological sourceHomo sapiens (human)
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Total number of polymer chains4
Total formula weight65411.66
Authors
Safo, M.K.,Abdulmalik, O.,Danso-Danquah, R.,Nokuri, S.,Joshi, G.S.,Musayev, F.N.,Asakura, T.,Abraham, D.J. (deposition date: 2003-09-05, release date: 2003-09-16, Last modification date: 2023-08-23)
Primary citationSafo, M.K.,Abdulmalik, O.,Danso-Danquah, R.,Burnett, J.C.,Nokuri, S.,Joshi, G.S.,Musayev, F.N.,Asakura, T.,Abraham, D.J.
Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds
J.Med.Chem., 47:4665-4676, 2004
Cited by
PubMed: 15341482
DOI: 10.1021/jm0498001
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

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