1QB1
Bovine Trypsin with 1-[2-[5-[amino(imino)methyl]-2-hydroxyphenoxy]-6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]piperidine-3-carboxylic Acid (ZK-806974)
Summary for 1QB1
Entry DOI | 10.2210/pdb1qb1/pdb |
Related | 1FAX 1MTU 1MTW 1QBN 1QBO |
Descriptor | PROTEIN (TRYPSIN), CALCIUM ION, 1-[2-[5-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-6-[3-(4,5-DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL)PHENOXY] PYRIDIN-4-YL]PIPERIDINE-3-CARBOXYLIC ACID, ... (4 entities in total) |
Functional Keywords | hydrolase, serine proteinase, protein-inhibitor complex, s1 pocket, factor xa |
Biological source | Bos taurus (cattle) |
Cellular location | Secreted, extracellular space: P00760 |
Total number of polymer chains | 1 |
Total formula weight | 23929.91 |
Authors | Whitlow, M. (deposition date: 1999-04-28, release date: 2000-04-29, Last modification date: 2018-01-24) |
Primary citation | Whitlow, M.,Arnaiz, D.O.,Buckman, B.O.,Davey, D.D.,Griedel, B.,Guilford, W.J.,Koovakkat, S.K.,Liang, A.,Mohan, R.,Phillips, G.B.,Seto, M.,Shaw, K.J.,Xu, W.,Zhao, Z.,Light, D.R.,Morrissey, M.M. Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin. Acta Crystallogr.,Sect.D, 55:1395-1404, 1999 Cited by PubMed: 10417407DOI: 10.1107/S0907444999007350 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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