1Q7G

Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline

Summary for 1Q7G

• Entry DOI: 10.2210/pdb1q7g/pdb
• Descriptor: Homoserine dehydrogenase, SODIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE-5-HYDROXY-4-OXONORVALINE, ... (4 entities in total)
• Functional Keywords: oxidoreductase
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Total number of polymer chains: 2
• Total formula weight: 77945.45

Authors

Jacques, S.L.,Mirza, I.A.,Ejim, L.,Koteva, K.,Hughes, D.W.,Green, K.,Kinach, R.,Honek, J.F.,Lai, H.K.,Berghuis, A.M.,Wright, G.D. (deposition date: 2003-08-18, release date: 2003-10-21, Last modification date: 2023-08-16)

• Primary citation: Jacques, S.L.,Mirza, I.A.,Ejim, L.,Koteva, K.,Hughes, D.W.,Green, K.,Kinach, R.,Honek, J.F.,Lai, H.K.,Berghuis, A.M.,Wright, G.D.; Enzyme assisted suicide: Molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase; Chem.Biol., 10:989-995, 2003; PubMed: 14583265; DOI: 10.1016/j.chembiol.2003.09.015

Experimental method

X-RAY DIFFRACTION (2.6 Å)