1Q7G

Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004412	molecular_function	homoserine dehydrogenase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0009067	biological_process	aspartate family amino acid biosynthetic process
A	0009086	biological_process	methionine biosynthetic process
A	0009088	biological_process	threonine biosynthetic process
A	0009090	biological_process	homoserine biosynthetic process
A	0009097	biological_process	isoleucine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0050661	molecular_function	NADP binding
A	0070403	molecular_function	NAD+ binding
B	0004412	molecular_function	homoserine dehydrogenase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0009067	biological_process	aspartate family amino acid biosynthetic process
B	0009086	biological_process	methionine biosynthetic process
B	0009088	biological_process	threonine biosynthetic process
B	0009090	biological_process	homoserine biosynthetic process
B	0009097	biological_process	isoleucine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0050661	molecular_function	NADP binding
B	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 500

Chain	Residue
A	GLU143
A	VAL146
A	GLY147
A	ALA148
A	LEU150

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 501

Chain	Residue
B	LEU150
B	GLU143
B	VAL146
B	GLY147
B	ALA148

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site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE NHO A 361

Chain	Residue
A	ILE11
A	GLY14
A	VAL15
A	VAL16
A	GLU40
A	ALA41
A	ASN92
A	THR93
A	SER94
A	ILE98
A	PRO115
A	LYS117
A	ALA144
A	SER174
A	GLY175
A	LYS223
A	GLY338
A	ALA339
A	GLY340
A	THR344
A	HOH501
A	HOH502

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Functional Information from PROSITE/UniProt

site_id	PS01042
Number of Residues	23
Details	HOMOSER_DHGENASE Homoserine dehydrogenase signature. AkklGYTep.DPrdDLnGlDvarK

Chain	Residue	Details
A	ALA201-LYS223

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000255

Chain	Residue	Details
A	LYS223
B	LYS223

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:10700284

Chain	Residue	Details
A	ILE11
A	THR93
A	LYS117
A	GLU208
B	ILE11
B	THR93
B	LYS117
B	GLU208

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
A	LYS290
B	LYS290

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ebf

Chain	Residue	Details
A	LYS223
A	ASP219

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ebf

Chain	Residue	Details
B	LYS223
B	ASP219

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site_id	MCSA1
Number of Residues	2
Details	M-CSA 521

Chain	Residue	Details
A	ASP219	electrostatic stabiliser
A	LYS223	proton shuttle (general acid/base)

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site_id	MCSA2
Number of Residues	2
Details	M-CSA 521

Chain	Residue	Details
B	ASP219	electrostatic stabiliser
B	LYS223	proton shuttle (general acid/base)

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