1PYE

Crystal structure of CDK2 with inhibitor

Summary for 1PYE

• Entry DOI: 10.2210/pdb1pye/pdb
• Related: 1PY5
• Descriptor: Cell division protein kinase 2, [2-AMINO-6-(2,6-DIFLUORO-BENZOYL)-IMIDAZO[1,2-A]PYRIDIN-3-YL]-PHENYL-METHANONE (3 entities in total)
• Functional Keywords: cdk, cyclin-dependent kinase 2, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 34353.83

Authors

Zhang, F.,Hamdouchi, C. (deposition date: 2003-07-08, release date: 2004-07-13, Last modification date: 2024-02-14)

• Primary citation: Hamdouchi, C.,Keyser, H.,Collins, E.,Jaramillo, C.,De Diego, J.E.,Spencer, C.D.,Dempsey, J.A.,Anderson, B.D.,Leggett, T.,Stamm, N.B.,Schultz, R.M.,Watkins, S.A.,Cocke, K.,Lemke, S.,Burke, T.F.,Beckmann, R.P.,Dixon, J.T.,Gurganus, T.M.,Rankl, N.B.,Houck, K.A.,Zhang, F.,Vieth, M.,Espinosa, J.,Timm, D.E.,Campbell, R.M.,Patel, B.K.,Brooks, H.B.; The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines.; MOL.CANCER THER., 3:1-9, 2004; PubMed: 14749470

Experimental method

X-RAY DIFFRACTION (2 Å)