1PY5

Crystal Structure of TGF-beta receptor I kinase with inhibitor

Summary for 1PY5

• Entry DOI: 10.2210/pdb1py5/pdb
• Related: 1PYE
• Descriptor: TGF-beta receptor type I, SULFATE ION, 4-(3-PYRIDIN-2-YL-1H-PYRAZOL-4-YL)QUINOLINE, ... (4 entities in total)
• Functional Keywords: tgf-beta, receptor i, kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P36897
• Total number of polymer chains: 1
• Total formula weight: 37470.96

Authors

Zhang, F.,Sawyer, J.S. (deposition date: 2003-07-08, release date: 2004-07-13, Last modification date: 2023-08-16)

• Primary citation: Sawyer, J.S.,Beight, D.W.,Britt, K.S.,Anderson, B.D.,Campbell, R.M.,Goodson, T.,Herron, D.K.,Li, H.Y.,McMillen, W.T.,Mort, N.,Parsons, S.,Smith, E.C.,Wagner, J.R.,Yan, L.,Zhang, F.,Yingling, J.M.; Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.; Bioorg.Med.Chem.Lett., 14:3581-3584, 2004; PubMed: 15177479; DOI: 10.1016/j.bmcl.2004.04.007

Experimental method

X-RAY DIFFRACTION (2.3 Å)