1O2G
Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors
Summary for 1O2G
Entry DOI | 10.2210/pdb1o2g/pdb |
Related | 1C5N |
Descriptor | THROMBIN, ACETYL HIRUDIN, SODIUM ION, ... (6 entities in total) |
Functional Keywords | serine protease, short hydrogen bond, inhibition mechanism, shift of pka, trypsin, thrombin, urokinase, factor xa, blood clotting, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28504 |
Total number of polymer chains | 3 |
Total formula weight | 35718.65 |
Authors | Katz, B.A.,Elrod, K.,Verner, E.,Mackman, R.L.,Luong, C.,Shrader, W.,Sendzik, M.,Spencer, J.R.,Sprengeler, P.A.,Kolesnikov, A.,Tai, W.F.,Hui, H.,Breitenbucher, G.,Allen, D.,Janc, J. (deposition date: 2003-03-06, release date: 2003-05-13, Last modification date: 2023-11-15) |
Primary citation | Katz, B.A.,Elrod, K.,Verner, E.,Mackman, R.L.,Luong, C.,Shrader, W.D.,Sendzik, M.,Spencer, J.R.,Sprengeler, P.A.,Kolesnikov, A.,Tai, V.W.-F.,Hui, H.C.,Breitenbucher, J.G.,Allen, D.,Janc, J.W. Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors J.Mol.Biol., 329:93-120, 2003 Cited by PubMed: 12742021DOI: 10.1016/S0022-2836(03)00399-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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