1C5N

STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR

Summary for 1C5N

• Entry DOI: 10.2210/pdb1c5n/pdb
• Descriptor: Thrombin light chain, Thrombin heavy chain, Hirudin, ... (7 entities in total)
• Functional Keywords: s1 site inhibitor, urokinase, trypsin, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P28504
• Total number of polymer chains: 3
• Total formula weight: 35606.36

Authors

Katz, B.A.,Mackman, R.,Luong, C.,Radika, K.,Martelli, A.,Sprengeler, P.A.,Wang, J.,Chan, H.,Wong, L. (deposition date: 1999-12-22, release date: 2000-12-22, Last modification date: 2023-11-15)

• Primary citation: Katz, B.A.,Mackman, R.,Luong, C.,Radika, K.,Martelli, A.,Sprengeler, P.A.,Wang, J.,Chan, H.,Wong, L.; Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.; Chem.Biol., 7:299-312, 2000; PubMed: 10779411; DOI: 10.1016/S1074-5521(00)00104-6

Experimental method

X-RAY DIFFRACTION (1.5 Å)