1NT1
thrombin in complex with selective macrocyclic inhibitor
Summary for 1NT1
Entry DOI | 10.2210/pdb1nt1/pdb |
Related | 1NM6 |
Descriptor | thrombin, Hirudin, (6R,21AS)-17-CHLORO-6-CYCLOHEXYL-2,3,6,7,10,11,19,20-OCTAHYDRO-1H,5H-PYRROLO[1,2-K][1,4,8,11,14]BENZOXATETRAAZA-CYCLOHEPTADECINE-5,8,12,21(9H,13H,21AH)-TETRONE, ... (4 entities in total) |
Functional Keywords | thrombin inhibitor complex, blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space: P00734 Secreted: P28504 |
Total number of polymer chains | 2 |
Total formula weight | 34961.41 |
Authors | Nantermet, P.G.,Barrow, J.C.,Newton, C.L.,Pellicore, J.M.,Young, M.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,McMasters, D.R.,Yan, Y.,Kuo, L.C.,Vacca, J.P.,Selnick, H.G. (deposition date: 2003-01-28, release date: 2003-09-02, Last modification date: 2017-10-11) |
Primary citation | Nantermet, P.G.,Barrow, J.C.,Newton, C.L.,Pellicore, J.M.,Young, M.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,McMasters, D.R.,Yan, Y.,Kuo, L.C.,Vacca, J.P.,Selnick, H.G. Design and synthesis of potent and selective macrocyclic thrombin inhibitors Bioorg.Med.Chem.Lett., 13:2781-2784, 2003 Cited by PubMed: 12873514DOI: 10.1016/S0960-894X(03)00506-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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