1NM6

thrombin in complex with selective macrocyclic inhibitor at 1.8A

Summary for 1NM6

• Entry DOI: 10.2210/pdb1nm6/pdb
• Related: 1NT1
• Descriptor: thrombin, Hirudin, (11S)-11-BENZYL-6-CHLORO-1,2,10,11,12,13,14,15,16,17,18,19-DODECAHYDRO-5,9-METHANO-2,5,8,10,13,17-BENZOHEXAAZACYCLOHENICOSINE-3,24-DIONE, ... (4 entities in total)
• Functional Keywords: thrombin inhibitor complex, blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space: P00734; Secreted: P28504
• Total number of polymer chains: 2
• Total formula weight: 35023.48

Authors

Nantermet, P.G.,Barrow, J.C.,Newton, C.L.,Pellicore, J.M.,Young, M.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,McMasters, D.R.,Yan, Y.,Kuo, L.C.,Vacca, J.P.,Selnick, H.G. (deposition date: 2003-01-09, release date: 2003-09-02, Last modification date: 2017-10-11)

• Primary citation: Nantermet, P.G.,Barrow, J.C.,Newton, C.L.,Pellicore, J.M.,Young, M.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,McMasters, D.R.,Yan, Y.,Kuo, L.C.,Vacca, J.P.,Selnick, H.G.; Design and synthesis of potent and selective macrocyclic thrombin inhibitors; Bioorg.Med.Chem.Lett., 13:2781-2784, 2003; PubMed: 12873514; DOI: 10.1016/S0960-894X(03)00506-7

Experimental method

X-RAY DIFFRACTION (1.8 Å)