1NHU
Hepatitis C virus RNA polymerase in complex with non-nucleoside analogue inhibitor
1NHU の概要
エントリーDOI | 10.2210/pdb1nhu/pdb |
分子名称 | HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE, (2S)-2-[(2,4-DICHLORO-BENZOYL)-(3-TRIFLUOROMETHYL-BENZYL)-AMINO]-3-PHENYL-PROPIONIC ACID (3 entities in total) |
機能のキーワード | hepatitis c; rna polymerase; enzyme inhibition, transferase |
由来する生物種 | Hepatitis C virus subtype 1b |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 129515.84 |
構造登録者 | Wang, M.,Ng, K.K.S.,Cherney, M.M.,Chan, L.,Yannopoulos, C.G.,Bedard, J.,Morin, N.,Nguyen-Ba, N.,Alaoui-Ismaili, M.H.,Bethell, R.C.,James, M.N.G. (登録日: 2002-12-19, 公開日: 2003-03-18, 最終更新日: 2023-08-16) |
主引用文献 | Wang, M.,Ng, K.K.S.,Cherney, M.M.,Chan, L.,Yannopoulos, C.G.,Bedard, J.,Morin, N.,Nguyen-Ba, N.,Alaoui-Ismaili, M.H.,Bethell, R.C.,James, M.N.G. Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition J.Biol.Chem., 278:9489-9495, 2003 Cited by PubMed: 12509436DOI: 10.1074/jbc.M209397200 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
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