1NDV

Crystal Structure of Adenosine Deaminase complexed with FR117016

Summary for 1NDV

Entry DOI	10.2210/pdb1ndv/pdb
Related	1NDW 1NDY 1NDZ
Descriptor	Adenosine deaminase, ZINC ION, N''-(4-(5-((1H-BENZIMIDAZOL-2-YLAMINO)METHYL)-2-THIENYL)-1,3-THIAZOL-2-YL)GUANIDINE, ... (4 entities in total)
Functional Keywords	structure-based drug design, beta barrel, inhibitor-induced conformational change, hydrolase
Biological source	Bos taurus (cattle)
Cellular location	Cell membrane; Peripheral membrane protein; Extracellular side (By similarity): P56658
Total number of polymer chains	1
Total formula weight	40776.55
Authors	Kinoshita, T. (deposition date: 2002-12-09, release date: 2003-12-09, Last modification date: 2024-03-13)
Primary citation	Terasaka, T.,Kinoshita, T.,Kuno, M.,Nakanishi, I. A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization J.Am.Chem.Soc., 126:34-35, 2004 Cited by PubMed: 14709046 DOI: 10.1021/ja038606l PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation