1N7I
The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and the inhibitor LY134046
Summary for 1N7I
Entry DOI | 10.2210/pdb1n7i/pdb |
Related | 1HNN |
Descriptor | Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 8,9-DICHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE, ... (4 entities in total) |
Functional Keywords | methyltransferase, catecholamine, adrenaline, epinephrine, s-adenosylmethionine, s-adenolsylhomocysteine, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 62977.00 |
Authors | McMillan, F.M.,Archbold, J.,McLeish, M.J.,Caine, J.M.,Criscione, K.R.,Grunewald, G.L.,Martin, J.L. (deposition date: 2002-11-15, release date: 2003-12-23, Last modification date: 2024-02-14) |
Primary citation | McMillan, F.M.,Archbold, J.,McLeish, M.J.,Caine, J.M.,Criscione, K.R.,Grunewald, G.L.,Martin, J.L. Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase. J.Med.Chem., 47:37-44, 2004 Cited by PubMed: 14695818DOI: 10.1021/jm0205752 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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